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Sergey Nejentsev


Amsterdam UMC, NL

Sergey Nejentsev is Professor of Translational Immunology at the Department of Molecular Cell Biology and Immunology (MCBI) in Amsterdam UMC. After graduating as paediatrician, Sergey did his PhD on genetics of type 1 diabetes and then worked as a postdoc with Prof John Todd in Cambridge. In 2008 he started his independent research group at the department of Medicine in the University of Cambridge investigating molecular mechanisms of immune-mediated disorders. He joined Amsterdam UMC in 2018 to continue these lines of research. Sergey was awarded the Royal Society University Research Fellowship and the Wellcome Trust Senior Fellowship in Basic Biomedical Science. His research was also funded by the ERC Starting and ERC Advanced grants, MRC Programme grant as well as project grants from EU FP7, EU H2020 and Wellcome Trust. He published >70 articles, including first-author and last-author papers in Nature, Science, Lancet, Nature Genetics and Nature Communications.


  • Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation
    Delphine Cuchet-Lourenço, Davide Eletto, Changxin Wu, Vincent Plagnol, Olivier Papapietro, James Curtis, Lourdes Ceron-Gutierrez, Chris M Bacon, Scott Hackett, Badr Alsaleem, Mailis Maes, Miguel Gaspar, Ali Alisaac, Emma Goss, Eman AlIdrissi, Daniela Siegmund, Harald Wajant, Dinakantha Kumararatne, Mofareh S AlZahrani, Peter D Arkwright, Mario Abinun, Rainer Doffinger, Sergey Nejentsev Science. 2018 Aug 24;361(6404):810-813
  • PI3Kδ and primary immunodeficiencies
    Lucas CL, Chandra A, Nejentsev S, Condliffe AM, Okkenhaug K. Nat Rev Immunol. 2016. 16(11):702-714.  Epub 2016 Sep 12. Review.
  • Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration.
    Curtis J, Luo Y, Zenner HL, Cuchet-Lourenço D, Wu C, Lo K, Maes M, Alisaac A, Stebbings E, Liu JZ, Kopanitsa L, Ignatyeva O, Balabanova Y, Nikolayevskyy V, Baessmann I, Thye T, Meyer CG, Nürnberg P, Horstmann RD, Drobniewski F, Plagnol V, Barrett JC, Nejentsev S. Nat Genet. 2015 May;47(5):523-527.
  • Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage
    Ivan Angulo, Oscar Vadas, Fabien Garçon, Edward Banham-Hall, Vincent Plagnol, Timothy R Leahy, Helen Baxendale, Tanya Coulter, James Curtis, Changxin Wu, Katherine Blake-Palmer, Olga Perisic, Deborah Smyth, Mailis Maes, Christine Fiddler, Jatinder Juss, Deirdre Cilliers, Gašper Markelj, Anita Chandra, George Farmer, Anna Kielkowska, Jonathan Clark, Sven Kracker, Marianne Debré, Capucine Picard, Isabelle Pellier, Nada Jabado, James A Morris, Gabriela Barcenas-Morales, Alain Fischer, Len Stephens, Phillip Hawkins, Jeffrey C Barrett, Mario Abinun, Menna Clatworthy, Anne Durandy, Rainer Doffinger, Edwin R Chilvers, Andrew J Cant, Dinakantha Kumararatne, Klaus Okkenhaug, Roger L Williams, Alison Condliffe, Sergey Nejentsev Science. 2013 Nov 15;342(6160):866-71.
  • Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes
    Nejentsev S, Walker N, Riches D, Egholm M, Todd JA. Science. 2009 Apr 17;324(5925):387-9. 
  • Localisation of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
    Nejentsev S, Howson JM, Walker NM, Szeszko J, Field SF, Stevens HE, Reynolds P, Hardy M, King E, Masters J, Hulme J, Maier LM, Smyth D, Bailey R, Cooper JD, Ribas G, Campbell RD, Clayton DG, Todd JA; Wellcome Trust Case Control Consortium Nature. 2007 Dec 6;450(7171):887-92.