Julie Guillermet-Guibert

Dr Julie Guillermet-Guibert is the leader of « SigDYN-Integrated cell signalling » research team, labelled by French Academic Research Institutions Inserm/CNRS/Université Paul Sabatier. Her laboratory is located in Centre de Recherches en Cancérologie de Toulouse, France. The questions underlying the following matters, “Which are the distinctive features of normal, cancer initiating and cancer cell signalling in physiopathological conditions? How can we use this knowledge for better diagnosis and therapy?”, has been the driving force in her career. She joined Inserm in 2010 as a permanent Researcher with the main objective of studying the unique biological features of oncogenic PI3K-driven signalling in pancreatic and ovarian biology. Cancer is one type of signalling disease where mutations, epigenetic events or organ context skew normal cell signalling. In this sense, the innovative genetically engineered mouse models developed in Guillermet-Guibert’s lab allows to decipher the biological mechanisms by which oncogenic pathways perturb normal tissue homeostasis. It helps to understand the multi-step process of the disease from the initiation to metastatic stages, as well as signalling adaptation to cancer treatments.

Publications

  • Phosphoproteomics Identifies PI3K Inhibitor-selective Adaptive Responses in Pancreatic Cancer Cell Therapy and Resistance
    Cintas C, Douche T, Dantes Z, Mouton-Barbosa E, Bousquet MP, Cayron C, Therville N, Pont F, Ramos-Delgado F, Guyon C, Garmy-Susini BH, Cappello P, Burlet-Schiltz O, Hirsch E, Gomez-Brouchet A, Thibault B, Reichert M, Guillermet-Guibert J Mol Cancer Ther. 2021 Dec;20(12):2433-2445. 
  • Is targeting autophagy a promising lead to unveil the cloak of invisibility in pancreatic cancer?
    Cayron C, Rigal S, Guillermet-Guibert J Clin Res Hepatol Gastroenterol. 2021 Mar 23;45(6):101622.
  • PI3K functions as a hub in mechanotransduction
    Di-Luoffo M, Ben-Meriem Z, Lefebvre P, Delarue M, Guillermet-Guibert J. Trends Biochem Sci. 2021 Nov;46(11):878-888.
  • Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
    Thibault B, Ramos-Delgado F, Pons-Tostivint E, Therville N, Cintas C, Arcucci S, Cassant-Sourdy S, Reyes-Castellanos G, Tosolini M, Villard AV, Cayron C, Baer R, Bertrand-Michel J, Pagan D, Ferreira Da Mota D, Yan H, Falcomatà C, Muscari F, Bournet B, Delord JP, Aksoy E, Carrier A, Cordelier P, Saur D, Basset C, Guillermet-Guibert J. EMBO Mol Med. 2021 May 25:e13502.
  • Organismal roles for the PI3Kα and β isoforms: their specificity, redundancy or cooperation is context-dependent
    Arcucci S, Ramos-Delgado F, Cayron C, Therville N, Gratacap MP, Basset C, Thibault B, Guillermet-Guibert J. Biochem J. 2021 Mar 26;478(6):1199-1225
  • Nuclear upregulation of class I phosphoinositide 3-kinase p110β correlates with high 47S rRNA levels in cancer cells
    Mazloumi Gavgani F, Karlsson T, Tangen IL, Morovicz AP, Arnesen VS, Turcu DC, Ninzima S, Spang K, Krakstad C, Guillermet-Guibert J, Lewis AE. J Cell Sci. 2021 Feb 10;134(3):jcs246090.  
  • Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis
    Soler A, Serra H, Pearce W, Angulo A, Guillermet-Guibert J, Friedman LS, Viñals F, Gerhardt H, Casanovas O, Graupera M, Vanhaesebroeck B. J Exp Med. 2013 Sep 23;210(10):1937-45.
  • The emerging mechanisms of isoform-specific PI3K signalling
    Bart Vanhaesebroeck, Julie Guillermet-Guibert, Mariona Graupera, Benoit Bilanges. Nat Rev Mol Cell Biol. 2010 May;11(5):329-41.
  • The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma
    Guillermet-Guibert J, Bjorklof K, Salpekar A, Gonella C, Ramadani F, Bilancio A, Meek S, Smith AJ, Okkenhaug K, Vanhaesebroeck B. Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8292-7. 
  • Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.
    Graupera M, Guillermet-Guibert J, Foukas LC, Phng LK, Cain RJ, Salpekar A, Pearce W, Meek S, Millan J, Cutillas PR, Smith AJ, Ridley AJ, Ruhrberg C, Gerhardt H, Vanhaesebroeck B. Nature. 2008 May 29;453(7195):662-6.