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Emilio Hirsch

Supervisor

Kither Biotech, Italy

Emilio Hirsch is Professor of Experimental Biology at the Medical School of the University of Torino. He authored 265 publications, has an h-index of 80 (google Scholar), is EMBO member, FISHR and Scientific Director of the Molinette Research Foundation. He provided seminal contributions in the characterization of phosphoinositide 3-kinases (PI3K) as drug targets in cancer and inflammation. He is founder of Kither Biotech, a preclinical stage biopharmaceutical company developing novel therapies for rare pulmonary diseases with high unmet medical needs like Cystic Fibrosis and Idiopathic Pulmonary Fibrosis.

ESR Student

 Janki Bhatt (ESR14)

Publications

  • Docking protein p130Cas regulates acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis
    Costamagna A, Natalini D, Leal MDPC, Simoni M, Gozzelino L, Cappello P, Novelli F, Ambrogio C, Defilippi P, Turco E, Giovannetti E, Hirsch E, Cabodi S, Martini M Gastroenterology. 2021 Dec 16:S0016-5085(21)04077-4.
  • PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation.
    Gulluni F, Prever L, Li H, Krafcikova P, Corrado I, Lo WT, Margaria JP, Chen A, De Santis MC, Cnudde SJ, Fogerty J, Yuan A, Massarotti A, Sarijalo NT, Vadas O, Williams RL, Thelen M, Powell DR, Schueler M, Wiesener MS, Balla T, Baris HN, Tiosano D, McDermott BM Jr, Perkins BD, Ghigo A, Martini M, Haucke V, Boura E, Merlo GR, Buchner DA, Hirsch E. Science. 2021 Dec 10;374(6573):eabk0410.
  • Phosphoproteomics Identifies PI3K Inhibitor-selective Adaptive Responses in Pancreatic Cancer Cell Therapy and Resistance
    Cintas C, Douche T, Dantes Z, Mouton-Barbosa E, Bousquet MP, Cayron C, Therville N, Pont F, Ramos-Delgado F, Guyon C, Garmy-Susini BH, Cappello P, Burlet-Schiltz O, Hirsch E, Gomez-Brouchet A, Thibault B, Reichert M, Guillermet-Guibert J Mol Cancer Ther. 2021 Dec;20(12):2433-2445. 
  • Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis
    Carlo C. Campa, Rangel L. Silva, Jean P. Margaria, Tracey Pirali, Matheus S. Mattos, Lucas R. Kraemer, Diego C. Reis, Giorgio Grosa, Francesca Copperi, Eduardo M. Dalmarco, Roberto C.P. Lima-Júnior, Silvio Aprile, Valentina Sala, Federica Dal Bello, Douglas Prado, Jose Carlos Alves-Filho, Claudio Medana, Giovanni D. Cassali, Gian Cesare Tron, Mauro M. Teixeira, Elisa Ciraolo, Remo C. Russo, Emilio Hirsch.
    Nat Commun. 2018 Dec 12;9(1):5232.
  • Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs
    Pirali T, Ciraolo E, Aprile S, Massarotti A, Berndt A, Griglio A, Serafini M, Mercalli V, Landoni C, Campa CC, Margaria JP, Silva RL, Grosa G, Sorba G, Williams R, Hirsch E, Tron GC Chem Med Chem. 2017 Sep 21;12(18):1542-1554.
  • Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ
    Perino A, Ghigo A, Ferrero E, Morello F, Santulli G, Baillie GS, Damilano F, Dunlop AJ, Pawson C, Walser R, Levi R, Altruda F, Silengo L, Langeberg LK, Neubauer G, Heymans S, Lembo G, Wymann MP, Wetzker R, Houslay MD, Iaccarino G, Scott JD, Hirsch E. Mol Cell. 2011 Apr 8;42(1):84-95.
  • Distinct effects of leukocyte and cardiac phosphoinositide 3-kinase γ activity in pressure overload-induced cardiac failure
    Damilano F, Franco I, Perrino C, Schaefer K, Azzolino O, Carnevale D, Cifelli G, Carullo P, Ragona R, Ghigo A, Perino A, Lembo G, Hirsch E. Circulation. 2011 Feb 1;123(4):391-9.
  • Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kgamma
    Vecchione C, Patrucco E, Marino G, Barberis L, Poulet R, Aretini A, Maffei A, Gentile MT, Storto M, Azzolino O, Brancaccio M, Colussi GL, Bettarini U, Altruda F, Silengo L, Tarone G, Wymann MP, Hirsch E, Lembo G. J Exp Med. 2005 Apr 18;201(8):1217-28.
  • PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects
    Patrucco E, Notte A, Barberis L, Selvetella G, Maffei A, Brancaccio M, Marengo S, Russo G, Azzolino O, Rybalkin SD, Silengo L, Altruda F, Wetzker R, Wymann MP, Lembo G, Hirsch E. Cell. 2004 Aug 6;118(3):375-87.
  • Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation
    Hirsch E, Katanaev VL, Garlanda C, Azzolino O, Pirola L, Silengo L, Sozzani S, Mantovani A, Altruda F, Wymann MP. Science. 2000 Feb 11;287(5455):1049-53.

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    This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 955534

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