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Jairo Rodriguez


qGenomics, Spain

Dr. Jairo Rodríguez has +20 years of experience in biomedical and basic research, both in academic and industrial settings. He received his Ph.D. from Institut d’Investigacions Biomèdiques de Bellvitge (IDIBELL) in 2008 we he was initially trained in cancer research, developing novel strategies to identify DNA methylation biomarkers that may be used in the early detection and/or management of colorectal cancer. Later, during his postdoctoral stay at Fred Hutchinson Cancer Research Center in Seattle, Dr. Rodríguez made broad use of different genomic approaches to study chromatin regulation in the context of DNA replication using budding yeast as a model organism, which earned him broad expertise in the generation and analysis of next generation sequencing data. At qGenomics, Dr. Rodríguez has directed the R&D department for the last 5 years, devising and implementing different genomic approaches where technology transfer is key, combining both wet lab and bioinformatics. Throughout the supervision of Ph.D. projects Dr. Rodriguez and his team have acquired a broad expertise in the manipulation and analysis of cell free DNA (cfDNA), mostly in the field of prenatal diagnosis and cancer monitoring. They have also developed methodologies that allow them to precisely identify ultra rare mutations in cfDNA with extreme accuracy to perform tumor monitoring. Looking into the future, Dr. Rodríguez’ long-term goals at qGenomics are to facilitate the diagnosis and monitoring of high-impact human diseases.


  • Disruption of NIPBL/Scc2 in Cornelia de Lange Syndrome provokes cohesin genome-wide redistribution with an impact in the transcriptome
    Garcia P, Fernandez-Hernandez R, Cuadrado A, Coca I, Gomez A, Maqueda M, Latorre-Pellicer A, Puisac B, Ramos FJ, Sandoval J, Esteller M, Mosquera JL, Rodriguez J, Pié J, Losada A, Queralt E. Nat Commun. 2021 Jul 27;12(1):4551
  • Nucleosome occupancy as a novel chromatin parameter for replication origin functions.
    Rodríguez J, Lee L, Lynch B, Tsukiyama T. Genome Res. 2017 Feb;27(2):269-277
  • In vivo conditional deletion of HDAC7 reveals its requirement to establish proper B lymphocyte identity and development
    Azagra A, Román-González L, Collazo O, Rodríguez-Ubreva J, de Yébenes VG, Barneda-Zahonero B, Rodríguez J, Castro de Moura M, Grego-Bessa J, Fernández-Duran I, Islam AB, Esteller M, Ramiro AR, Ballestar E, Parra M. J Exp Med. 2016 Nov 14;213(12):2591-2601
  • ATR-like kinase Mec1 facilitates both chromatin accessibility at DNA replication forks and replication fork progression during replication stress.
    Rodriguez J, Tsukiyama T. Genes Dev. 2013 Jan 1;27(1):74-86. 
  • Bivalent domains enforce transcriptional memory of DNA methylated genes in colon cancer cells.
    Rodriguez J, Muñoz M, Vives L, Frangou C, Groudine M, Peinado M. Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19809-14.