PUBLICATIONS

2021

• Docking protein p130Cas regulates acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis

  Costamagna A, Natalini D, Leal MDPC, Simoni M, Gozzelino L, Cappello P, Novelli F, Ambrogio C, Defilippi P, Turco E, Giovannetti E, Hirsch E, Cabodi S, Martini M Gastroenterology. 2021 Dec 16:S0016-5085(21)04077-4.

• PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation.

  Gulluni F, Prever L, Li H, Krafcikova P, Corrado I, Lo WT, Margaria JP, Chen A, De Santis MC, Cnudde SJ, Fogerty J, Yuan A, Massarotti A, Sarijalo NT, Vadas O, Williams RL, Thelen M, Powell DR, Schueler M, Wiesener MS, Balla T, Baris HN, Tiosano D, McDermott BM Jr, Perkins BD, Ghigo A, Martini M, Haucke V, Boura E, Merlo GR, Buchner DA, Hirsch E. Science. 2021 Dec 10;374(6573):eabk0410.

• Red flags for early recognition of adult patients with PTEN Hamartoma Tumour Syndrome

  Drissen MMCM, Schieving JH, Schuurs-Hoeijmakers JHM, Vos JR, Hoogerbrugge N Eur J Med Genet. 2021 Dec;64(12):104364.

• Phosphoproteomics Identifies PI3K Inhibitor-selective Adaptive Responses in Pancreatic Cancer Cell Therapy and Resistance

  Cintas C, Douche T, Dantes Z, Mouton-Barbosa E, Bousquet MP, Cayron C, Therville N, Pont F, Ramos-Delgado F, Guyon C, Garmy-Susini BH, Cappello P, Burlet-Schiltz O, Hirsch E, Gomez-Brouchet A, Thibault B, Reichert M, Guillermet-Guibert J Mol Cancer Ther. 2021 Dec;20(12):2433-2445. 

• Activated PI3Kδ syndrome, an immunodeficiency disorder, leads to sensorimotor deficits recapitulated in a murine model

  Serra I, Manusama OR, Kaiser FMP, Floriano II, Wahl L, van der Zalm C, Ijspeert H. van Hagen PM,  van Beveren NJM, Arend SM, Okkenhaugg K, Pel JJM, Dalm VASH, Badura A Brain Behav Immun Health. 2021 Oct 19;18:100377. 

• Is targeting autophagy a promising lead to unveil the cloak of invisibility in pancreatic cancer?

  Cayron C, Rigal S, Guillermet-Guibert J Clin Res Hepatol Gastroenterol. 2021 Mar 23;45(6):101622.

• Molecular diagnosis of T-cell lymphoma: a correlative study of PCR-based T-cell clonality assessment and targeted NGS.

  Syrykh C, Gorez P, Péricart S, Grand D, Escudié F, Cabarrou B, Obéric L, Ysebaert L, Lamant L, Laurent C, Evrard SM, Brousset P. Blood Adv 2021;5(22):4590-4593.

• PI3K functions as a hub in mechanotransduction

  Di-Luoffo M, Ben-Meriem Z, Lefebvre P, Delarue M, Guillermet-Guibert J. Trends Biochem Sci. 2021 Nov;46(11):878-888.

• PI3K inhibitors are finally coming of age

  Vanhaesebroeck B, Perry MWD, Brown JR, André F, Okkenhaug K. Nat Rev Drug Discov. 2021. 14.

• Phased differentiation of γδ T and T CD8 tumor-infiltrating lymphocytes revealed by single-cell transcriptomics of human cancers

  Cerapio JP, Perrier M, Balança CC, Gravelle P, Pont F, Devaud C, Franchini DM, Féliu V, Tosolini M, Valle C, Lopez F, Quillet-Mary A, Ysebaert L, Martinez A, Delord JP, Ayyoub M, Laurent C, Fournie JJ. Oncoimmunology. 2021;10(1).

• Determinants and Reference Ranges of Serum Immunoglobulins in Middle-Aged and Elderly Individuals: a Population-Based Study

  Khan SR, Chaker L, Ikram MA, Peeters RP, van Hagen PM, Dalm VASH. J Clin Immunol. 2021 Sep 10. doi: 10.1007

• Disruption of NIPBL/Scc2 in Cornelia de Lange Syndrome provokes cohesin genome-wide redistribution with an impact in the transcriptome

  Garcia P, Fernandez-Hernandez R, Cuadrado A, Coca I, Gomez A, Maqueda M, Latorre-Pellicer A, Puisac B, Ramos FJ, Sandoval J, Esteller M, Mosquera JL, Rodriguez J, Pié J, Losada A, Queralt E. Nat Commun. 2021 Jul 27;12(1):4551

• Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component

  Thibault B, Ramos-Delgado F, Pons-Tostivint E, Therville N, Cintas C, Arcucci S, Cassant-Sourdy S, Reyes-Castellanos G, Tosolini M, Villard AV, Cayron C, Baer R, Bertrand-Michel J, Pagan D, Ferreira Da Mota D, Yan H, Falcomatà C, Muscari F, Bournet B, Delord JP, Aksoy E, Carrier A, Cordelier P, Saur D, Basset C, Guillermet-Guibert J. EMBO Mol Med. 2021 May 25:e13502.

• Soluble Interleukin-2 Receptor Is a Promising Serum Biomarker for Granulomatous Disease in Common Variable Immune Deficiency

  van Stigt AC, Dalm VASH, Nagtzaam NMA, van Rijswijk DA, Barendregt BH, van Hagen PM, IJspeert H, Dik WA. J Clin Immunol. 2021 Apr;41(3):694-697

• Organismal roles for the PI3Kα and β isoforms: their specificity, redundancy or cooperation is context-dependent

  Arcucci S, Ramos-Delgado F, Cayron C, Therville N, Gratacap MP, Basset C, Thibault B, Guillermet-Guibert J. Biochem J. 2021 Mar 26;478(6):1199-1225

• Nuclear upregulation of class I phosphoinositide 3-kinase p110β correlates with high 47S rRNA levels in cancer cells

  Mazloumi Gavgani F, Karlsson T, Tangen IL, Morovicz AP, Arnesen VS, Turcu DC, Ninzima S, Spang K, Krakstad C, Guillermet-Guibert J, Lewis AE. J Cell Sci. 2021 Feb 10;134(3):jcs246090.  

• Lymphoma Heterogeneity Unraveled by Single-Cell Transcriptomics.

  Ysebaert L, Quillet-Mary A, Tosolini M, Pont F, Laurent C, Fournié JJ. Front Immunol. 2021;12: 597651.

• A review on age-related cancer risks in PTEN hamartoma tumor syndrome

  Hendricks LAJ , Hoogerbrugge N, Schuurs-Hoeijmakers JHM, Vos JR Clin Genet. 2021 Feb;99(2):219-225.

2020

• Effects of novel Btk and Syk inhibitors on platelet functions alone and in combination in vitro and in vivo.

  Series J, Ribes A, Garcia C, Souleyreau P, Bauters A, Morschhauser F, Jürgensmeier JM, Sié P, Ysebaert L, Payrastre B. J Thromb Haemost. 2020;18(12):3336-3351.

• Phosphoinositide 3-Kinase-Regulated Pericyte Maturation Governs Vascular Remodeling.

  Figueiredo AM, Villacampa P, Diéguez-Hurtado R, José Lozano J, Kobialka P, Cortazar AR, Martinez-Romero A, Angulo-Urarte A, Franco CA, Claret M, Aransay AM, Adams RH, Carracedo A, Graupera M. Circulation. 2020 Aug 18;142(7):688-704.

• Cancer Surveillance Guideline for individuals with PTEN hamartoma tumour syndrome

  Tischkowitz M, Colas C, Pouwels S, Hoogerbrugge N; PHTS Guideline Development Group; European Reference Network GENTURIS Eur J Hum Genet. 2020 Oct;28(10):1387-1393.

• Diagnosis and Treatment of Chronic Lymphocytic Leukemia: Recommendations of the French CLL Study Group (FILO).

  Quinquenel A, Aurran-Schleinitz T, Clavert A, Cymbalista F, Dartigeas C, Davi F, de Guibert S, Delmer A, Dilhuydy MS, Feugier P, Fornecker LM, Ghez D, Guieze R, Laribi K, Leblond V, Leprêtre S, Letestu R, Lévy V, Nguyen-Khac F, Michallet AS, Tomowiak C, Tournilhac O, Ysebaert L, Troussard X. Hemasphere. 2020;4(5):e473.

• Recommendations on Surveillance for Differentiated Thyroid Carcinoma in Children with PTEN Hamartoma Tumor Syndrome

  Jonker LA, Lebbink CA, Jongmans MCJ, Nievelstein RAJ, Merks JHM, Nieveen van Dijkum EJM, Links TP, Hoogerbrugge N, van Trotsenburg ASP, van Santen HM Eur Thyroid J. 2020 Sep;9(5):234-242.

• Lenalidomide/rituximab induces high molecular response in untreated follicular lymphoma: LYSA ancillary RELEVANCE study.

  Delfau-Larue MH, Boulland ML, Beldi-Ferchiou A, Feugier P, Maisonneuve H, Casasnovas RO, Lemonnier F, Pica GM, Houot R, Ysebaert L, Tilly H, Eisenmann JC, Le Gouill S, Ribrag V, Godmer P, Glaisner S, Cartron G, Xerri L, Salles GA, Fest T, Morschhauser F. Blood Adv. 2020;4(14):3217-3223.

• Immunomodulatory Agents in Follicular Lymphoma.

  Ysebaert L, Morschhauser F. Hematol Oncol Clin North Am. 2020 Aug;34(4):715-726.

• Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation.

  Martinez-Corral I, Zhang Y, Petkova M, Ortsäter H, Sjöberg S, Castillo SD, Brouillard P, Libbrecht L, Saur D, Graupera M, Alitalo K, Boon L, Vikkula M, Mäkinen T. Nat Commun. 2020 Jun 8;11(1):2869. 

• Genetic manipulation of LKB1 elicits lethal metastatic prostate cancer.

  Hermanova I, Zúñiga-García P, Caro-Maldonado A, Fernandez-Ruiz S, Salvador F, Martín-Martín N, Zabala-Letona A, Nuñez-Olle M, Torrano V, Camacho L, Lizcano JM, Talamillo A, Carreira S, Gurel B, Cortazar AR, Guiu M, López JI, Martinez-Romero A, Astobiza I, Valcarcel-Jimenez L, Lorente M, Arruabarrena-Aristorena A, Velasco G, Gomez-Muñoz A, Suárez-Cabrera C, Lodewijk I, Flores JM, Sutherland JD, Barrio R, de Bono JS, Paramio JM, Trka J, Graupera M, Gomis RR, Carracedo A. J Exp Med. 2020 Jun 1;217(6):e20191787. 

• Universal Tumor DNA BRCA1/2 Testing of Ovarian Cancer: Prescreening PARPi Treatment and Genetic Predisposition

  CVos JR, Fakkert IE, de Hullu JA, van Altena AM, Sie AS, Ouchene H, Willems RW, Nagtegaal ID, Jongmans MCJ, Mensenkamp AR, Woldringh GH, Bulten J, Leter EM, Kets CM, Simons M, Ligtenberg MJL, Hoogerbrugge N J Natl Cancer Inst. 2020 Feb 1;112(2):161-169.

2019

• Sustained Progression-Free Survival Benefit of Rituximab Maintenance in Patients With Follicular Lymphoma: Long-Term Results of the PRIMA Study.

  Bachy E, Seymour JF, Feugier P, Offner F, López-Guillermo A, Belada D, Xerri L, Catalano JV, Brice P, Lemonnier F, Martin A, Casasnovas O, Pedersen LM, Dorvaux V, Simpson D, Leppa S, Gabarre J, da Silva MG, Glaisner S, Ysebaert L, Vekhoff A, Intragumtornchai T, Le Gouill S, Lister A, Estell JA, Milone G, Sonet A, Farhi J, Zeuner H, Tilly H, Salles G. J Clin Oncol. 2019;37(31):2815-2824.

• PI3K isoforms in cell signalling and vesicle trafficking

  Benoit Bilanges, York Posor, Bart Vanhaesebroeck. Nat Rev Mol Cell Biol. 2019 Sep;20(9):515-534.

• PIK3CA mutations in vascular malformations

  Castillo SD, Baselga E, Graupera M. Curr Opin Hematol. 2019 May;26(3):170-178. 

• Effect of PTEN inactivating germline mutations on innate immune cell function and thyroid cancer-induced macrophages in patients with PTEN hamartoma tumor syndrome

  Sloot YJE, Rabold K, Netea MG, Smit JWA, Hoogerbrugge N, Netea-Maier RT Oncogene. 2019 May;38(19):3743-3755.

• Boosting care and knowledge about hereditary cancer: European Reference Network on Genetic Tumour Risk Syndromes

  Vos JR, Giepmans L, Röhl C, Geverink N, Hoogerbrugge N; ERN GENTURIS Fam Cancer. 2019 Apr;18(2):281-284.

• Multiparametric analysis of CD8+ T cell compartment phenotype in chronic lymphocytic leukemia reveals a signature associated with progression toward therapy.

  Gonnord P, Costa M, Abreu A, Peres M, Ysebaert L, Gadat S, Valitutti S. Oncoimmunology. 2019;8(4):e1570774.

• PTEN Hamartoma Tumor Syndrome and Immune Dysregulation

  Eissing M, Ripken L, Schreibelt G, Westdorp H, Ligtenberg M, Netea-Maier R, Netea MG, de Vries IJM, Hoogerbrugge N Transl Oncol. 2019 Feb; 12(2): 361–367.

• Mutational Signature Analysis Reveals NTHL1 Deficiency to Cause a Multi-tumor Phenotype

  Grolleman JE, de Voer RM, Elsayed FA, Nielsen M, Weren RDA, Palles C, Ligtenberg MJL, Vos JR, et al Hoogerbrugge N and Kuiper R Cancer Cell. 2019 Feb 11;35(2):256-266.e5

2018

• Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis

  Carlo C. Campa, Rangel L. Silva, Jean P. Margaria, Tracey Pirali, Matheus S. Mattos, Lucas R. Kraemer, Diego C. Reis, Giorgio Grosa, Francesca Copperi, Eduardo M. Dalmarco, Roberto C.P. Lima-Júnior, Silvio Aprile, Valentina Sala, Federica Dal Bello, Douglas Prado, Jose Carlos Alves-Filho, Claudio Medana, Giovanni D. Cassali, Gian Cesare Tron, Mauro M. Teixeira, Elisa Ciraolo, Remo C. Russo, Emilio Hirsch.
  Nat Commun. 2018 Dec 12;9(1):5232.

• Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility.

  Angulo-Urarte A, Casado P, Castillo SD, Kobialka P, Kotini MP, Figueiredo AM, Castel P, Rajeeve V, Milà-Guasch M, Millan J, Wiesner C, Serra H, Muixi L, Casanovas O, Viñals F, Affolter M, Gerhardt H, Huveneers S, Belting HG, Cutillas PR, Graupera M. Nat Commun. 2018 Nov 16;9(1):4826.

• Phosphatidylinositol 3-Kinase, Growth Disorders, and Cancer

  Marcus D Goncalves , Benjamin D Hopkins , Lewis C Cantley
  N Engl J Med. 2018 Nov 22;379(21):2052-2062

• Rituximab plus Lenalidomide in Advanced Untreated Follicular Lymphoma.

  Morschhauser F, Fowler NH, Feugier P, Bouabdallah R, Tilly H, Palomba ML, Fruchart C, Libby EN, Casasnovas RO, Flinn IW, Haioun C, Maisonneuve H, Ysebaert L, Bartlett NL, Bouabdallah K, Brice P, Ribrag V, Daguindau N, Le Gouill S, Pica GM, Martin Garcia-Sancho A, López-Guillermo A, Larouche JF, Ando K, Gomes da Silva M, André M, Zachée P, Sehn LH, Tobinai K, Cartron G, Liu D, Wang J, Xerri L, Salles GA; RELEVANCE Trial Investigators. N Engl J Med. 2018;379(10):934-947.

• The functions and regulation of the PTEN tumour suppressor: new modes and prospects

  Yu-Ru Lee , Ming Chen , Pier Paolo Pandolfi. Nat Rev Mol Cell Biol. 2018 Sep;19(9):547-562.

• Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation

  Delphine Cuchet-Lourenço, Davide Eletto, Changxin Wu, Vincent Plagnol, Olivier Papapietro, James Curtis, Lourdes Ceron-Gutierrez, Chris M Bacon, Scott Hackett, Badr Alsaleem, Mailis Maes, Miguel Gaspar, Ali Alisaac, Emma Goss, Eman AlIdrissi, Daniela Siegmund, Harald Wajant, Dinakantha Kumararatne, Mofareh S AlZahrani, Peter D Arkwright, Mario Abinun, Rainer Doffinger, Sergey Nejentsev Science. 2018 Aug 24;361(6404):810-813

• Baricitinib treatment in a patient with a gain-of-function mutation in signal transducer and activator of transcription 1 (STAT1)

  Meesilpavikkai K, Dik WA, Schrijver B, Nagtzaam NMA, Posthumus-van Sluijs SJ, van Hagen PM, Dalm VASH. J Allergy Clin Immunol. 2018 Jul;142(1):328-330.e2

• Targeted therapy in patients with PIK3CA-related overgrowth syndrome.

  Venot Q, Blanc T, Rabia SH, Berteloot L, Ladraa S, Duong JP, Blanc E, Johnson SC, Hoguin C, Boccara O, Sarnacki S, Boddaert N, Pannier S, Martinez F, Magassa S, Yamaguchi J, Knebelmann B, Merville P, Grenier N, Joly D, Cormier-Daire V, Michot C, Bole-Feysot C, Picard A, Soupre V, Lyonnet S, Sadoine J, Slimani L, Chaussain C, Laroche-Raynaud C, Guibaud L, Broissand C, Amiel J, Legendre C, Terzi F, Canaud G. Nature. 2018 Jun;558(7711):540-546. 

• High Yield of Pathogenic Germline Mutations Causative or Likely Causative of the Cancer Phenotype in Selected Children with Cancer

  Diets I, Waanders E, Ligtenberg MJL, Bladel DV, Kamping EJ, Hoogerbrugge PM, Hopman S, Olderode-Berends MJW, Gerkes EH, Koolen D, Marcelis C, Santen GW, Belzen MV, Mordaunt D, McGregor L, Thompson E, Kattamis A, Pastorczak A, Mlynarski W, Ilencikova D, Vulto-van Silfhout A, Gardeitchik T, de Bont ESJM, Loeffen J, Wagner A, Mensenkamp AR, Kuiper RP*, Hoogerbrugge N*, Jongmans M* Clin Cancer Res. 2018 Apr 1;24(7):1594-1603.

2017

• Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.

  Berenjeno IM, Piñeiro R, Castillo SD, Pearce W, McGranahan N, Dewhurst SM, Meniel V, Birkbak NJ, Lau E, Sansregret L, Morelli D, Kanu N, Srinivas S, Graupera M, Parker VER, Montgomery KG, Moniz LS, Scudamore CL, Phillips WA, Semple RK, Clarke A, Swanton C, Vanhaesebroeck B. Nat Commun. 2017 Nov 24;8(1):1773.

• Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

  Bilanges B, Alliouachene S, Pearce W, Morelli D, Szabadkai G, Chung YL, Chicanne G, Valet C, Hill JM, Voshol PJ, Collinson L, Peddie C, Ali K, Ghazaly E, Rajeeve V, Trichas G, Srinivas S, Chaussade C, Salamon RS, Backer JM, Scudamore CL, Whitehead MA, Keaney EP, Murphy LO, Semple RK, Payrastre B, Tooze SA, Vanhaesebroeck B Nat Commun. 2017 Nov 27;8(1):1804.

• Idiopathic pulmonary fibrosis

  Fernando J Martinez, Harold R Collard, Annie Pardo, Ganesh Raghu, Luca Richeldi, Moises Selman, Jeffrey J Swigris, Hiroyuki Taniguchi, Athol U Wells
  Review Nat Rev Dis Primers. 2017 Oct 20;3:17074

• Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs

  Pirali T, Ciraolo E, Aprile S, Massarotti A, Berndt A, Griglio A, Serafini M, Mercalli V, Landoni C, Campa CC, Margaria JP, Silva RL, Grosa G, Sorba G, Williams R, Hirsch E, Tron GC Chem Med Chem. 2017 Sep 21;12(18):1542-1554.

• The PI3K Pathway in Human Disease

  David A Fruman, Honyin Chiu, Benjamin D Hopkins, Shubha Bagrodia, Lewis C Cantley, Robert T Abraham Cell. 2017 Aug 10;170(4):605-635.

• Nucleosome occupancy as a novel chromatin parameter for replication origin functions.

  Rodríguez J, Lee L, Lynch B, Tsukiyama T. Genome Res. 2017 Feb;27(2):269-277

2016

• Phosphoinositide 3-kinase: a new kid on the block in vascular anomalies.

  Castillo SD, Vanhaesebroeck B, Sebire NJ. J Pathol. 2016 Dec;240(4):387-396.

• In vivo conditional deletion of HDAC7 reveals its requirement to establish proper B lymphocyte identity and development

  Azagra A, Román-González L, Collazo O, Rodríguez-Ubreva J, de Yébenes VG, Barneda-Zahonero B, Rodríguez J, Castro de Moura M, Grego-Bessa J, Fernández-Duran I, Islam AB, Esteller M, Ramiro AR, Ballestar E, Parra M. J Exp Med. 2016 Nov 14;213(12):2591-2601

• PI3Kδ and primary immunodeficiencies

  Lucas CL, Chandra A, Nejentsev S, Condliffe AM, Okkenhaug K. Nat Rev Immunol. 2016. 16(11):702-714.  Epub 2016 Sep 12. Review.

• Targeting PI3K in Cancer: Impact on Tumor Cells, Their Protective Stroma, Angiogenesis, and Immunotherapy

  Okkenhaug K, Graupera M, Vanhaesebroeck B. Cancer Discov. 2016. 6(10):1090-1105. 

• Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice

  Alliouachene S, Bilanges B, Chaussade C, Pearce W, Foukas LC, Scudamore CL, Moniz LS, Vanhaesebroeck B. Diabetologia. 2016 Jul;59(7):1503-12.

• Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans

  Sandra D Castillo, Elena Tzouanacou, May Zaw-Thin, Inma M Berenjeno, Victoria E R Parker, Iñigo Chivite, Maria Milà-Guasch, Wayne Pearce, Isabelle Solomon, Ana Angulo-Urarte, Ana M Figueiredo, Robert E Dewhurst, Rachel G Knox, Graeme R Clark , Cheryl L Scudamore, Adam Badar, Tammy L Kalber, Julie Foster, Daniel J Stuckey, Anna L David , Wayne A Phillips, Mark F Lythgoe, Valerie Wilson, Robert K Semple, Neil J Sebire, Veronica A Kinsler, Mariona Graupera, Bart Vanhaesebroeck Sci Transl Med. 2016 Mar 30;8(332):332ra43.

2015

• Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity

  Alliouachene S, Bilanges B, Chicanne G, Anderson KE, Pearce W, Ali K, Valet C, Posor Y, Low PC, Chaussade C, Scudamore CL, Salamon RS, Backer JM, Stephens L, Hawkins PT, Payrastre B, Vanhaesebroeck B. Cell Rep. 2015 Dec 1;13(9):1881-94.

• Accuracy of Hereditary Diffuse Gastric Cancer Testing Criteria and Outcomes in Patients With a Germline Mutation in CDH1

  Rachel S van der Post, Ingrid P Vogelaar, Peggy Manders, Lizet E van der Kolk, Annemieke Cats, Liselotte P van Hest, Rolf Sijmons, Cora M Aalfs, Margreet G E M Ausems, Encarna B Gómez García, Anja Wagner, Frederik J Hes, Neeltje Arts, Arjen R Mensenkamp, J Han van Krieken, Nicoline Hoogerbrugge, Marjolijn J L Ligtenberg Gastroenterology. 2015 Oct;149(4):897-906.e19.

• PI3K inhibitors in inflammation, autoimmunity and cancer

  Stark AK, Sriskantharajah S, Hessel EM, Okkenhaug K. Curr Opin Pharmacol. 2015. 23:82-91. 

• Bias Correction Methods Explain Much of the Variation Seen in Breast Cancer Risks of BRCA1/2 Mutation Carriers

  Janet R Vos, Li Hsu, Richard M Brohet, Marian J E Mourits, Jakob de Vries, Kathleen E Malone, Jan C Oosterwijk, Geertruida H de Bock J Clin Oncol. 2015 Aug 10;33(23):2553-62.

• Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration.

  Curtis J, Luo Y, Zenner HL, Cuchet-Lourenço D, Wu C, Lo K, Maes M, Alisaac A, Stebbings E, Liu JZ, Kopanitsa L, Ignatyeva O, Balabanova Y, Nikolayevskyy V, Baessmann I, Thye T, Meyer CG, Nürnberg P, Horstmann RD, Drobniewski F, Plagnol V, Barrett JC, Nejentsev S. Nat Genet. 2015 May;47(5):523-527.

• Cystic fibrosis

  Felix Ratjen, Scott C Bell, Steven M Rowe, Christopher H Goss, Alexandra L Quittner, Andrew Bush Review Nat Rev Dis Primers. 2015 May 14;1:15010.

• PTEN mediates Notch-dependent stalk cell arrest in angiogenesis

  Serra H, Chivite I, Angulo-Urarte A, Soler A, Sutherland JD, Arruabarrena-Aristorena A, Ragab A, Lim R, Malumbres M, Fruttiger M, Potente M, Serrano M, Fabra À, Viñals F, Casanovas O, Pandolfi PP, Bigas A, Carracedo A, Gerhardt H, Graupera M. Nat Commun. 2015 Jul 31;6:7935.

2014

• Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer

  Ali K, Soond DR, Piñeiro R, Hagemann T, Pearce W, Lim EL, Bouabe H, Scudamore CL, Hancox T, Maecker H, Friedman L, Turner M, Okkenhaug K, Vanhaesebroeck B. Nature. 2014 Jun 19;509(7505):407-11.

2013

• Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage

  Ivan Angulo, Oscar Vadas, Fabien Garçon, Edward Banham-Hall, Vincent Plagnol, Timothy R Leahy, Helen Baxendale, Tanya Coulter, James Curtis, Changxin Wu, Katherine Blake-Palmer, Olga Perisic, Deborah Smyth, Mailis Maes, Christine Fiddler, Jatinder Juss, Deirdre Cilliers, Gašper Markelj, Anita Chandra, George Farmer, Anna Kielkowska, Jonathan Clark, Sven Kracker, Marianne Debré, Capucine Picard, Isabelle Pellier, Nada Jabado, James A Morris, Gabriela Barcenas-Morales, Alain Fischer, Len Stephens, Phillip Hawkins, Jeffrey C Barrett, Mario Abinun, Menna Clatworthy, Anne Durandy, Rainer Doffinger, Edwin R Chilvers, Andrew J Cant, Dinakantha Kumararatne, Klaus Okkenhaug, Roger L Williams, Alison Condliffe, Sergey Nejentsev Science. 2013 Nov 15;342(6160):866-71.

• Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis

  Soler A, Serra H, Pearce W, Angulo A, Guillermet-Guibert J, Friedman LS, Viñals F, Gerhardt H, Casanovas O, Graupera M, Vanhaesebroeck B. J Exp Med. 2013 Sep 23;210(10):1937-45.

• Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism.

  Foukas LC, Bilanges B, Bettedi L, Pearce W, Ali K, Sancho S, Withers DJ, Vanhaesebroeck B. EMBO Mol Med. 2013 Apr;5(4):563-71. 

• ATR-like kinase Mec1 facilitates both chromatin accessibility at DNA replication forks and replication fork progression during replication stress.

  Rodriguez J, Tsukiyama T. Genes Dev. 2013 Jan 1;27(1):74-86. 

• Signaling by the phosphoinositide 3-kinase family in immune cells

  Okkenhaug K Annu Rev Immunol. 2013;31:675-704. 

2012

• The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock

  Aksoy E, Taboubi S, Torres D, Delbauve S, Hachani A, Whitehead MA, Pearce WP, Berenjeno-Martin I, Nock G, Filloux A, Beyaert R, Flamand V, Vanhaesebroeck B. Nature Immunol. 2012 Nov;13(11):1045-54.

• Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA

  Marjorie J Lindhurst, Victoria E R Parker, Felicity Payne, Julie C Sapp, Simon Rudge, Julie Harris, Alison M Witkowski, Qifeng Zhang, Matthijs P Groeneveld, Carol E Scott, Allan Daly, Susan M Huson, Laura L Tosi, Michael L Cunningham, Thomas N Darling, Joseph Geer, Zoran Gucev, V Reid Sutton, Christos Tziotzios, Adrian K Dixon, Timothy Helliwell, Stephen O'Rahilly, David B Savage, Michael J O Wakelam, Inês Barroso, Leslie G Biesecker, Robert K Semple Nat Genet. 2012 Jun 24;44(8):928-33

2011

• Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ

  Perino A, Ghigo A, Ferrero E, Morello F, Santulli G, Baillie GS, Damilano F, Dunlop AJ, Pawson C, Walser R, Levi R, Altruda F, Silengo L, Langeberg LK, Neubauer G, Heymans S, Lembo G, Wymann MP, Wetzker R, Houslay MD, Iaccarino G, Scott JD, Hirsch E. Mol Cell. 2011 Apr 8;42(1):84-95.

• Distinct effects of leukocyte and cardiac phosphoinositide 3-kinase γ activity in pressure overload-induced cardiac failure

  Damilano F, Franco I, Perrino C, Schaefer K, Azzolino O, Carnevale D, Cifelli G, Carullo P, Ragona R, Ghigo A, Perino A, Lembo G, Hirsch E. Circulation. 2011 Feb 1;123(4):391-9.

• Risk of colorectal and endometrial cancers in EPCAM deletion-positive Lynch syndrome: a cohort study

  Marlies J E Kempers, Roland P Kuiper, Charlotte W Ockeloen, Pierre O Chappuis, Pierre Hutter, Nils Rahner, Hans K Schackert, Verena Steinke, Elke Holinski-Feder, Monika Morak, Matthias Kloor, Reinhard Büttner, Eugene T P Verwiel, J Han van Krieken, Iris D Nagtegaal, Monique Goossens, Rachel S van der Post, Renée C Niessen, Rolf H Sijmons, Irma Kluijt, Frans B L Hogervorst, Edward M Leter, Johan J P Gille, Cora M Aalfs, Egbert J W Redeker, Frederik J Hes, Carli M J Tops, Bernadette P M van Nesselrooij, Marielle E van Gijn, Encarna B Gómez García, Diana M Eccles, David J Bunyan, Sapna Syngal, Elena M Stoffel, Julie O Culver, Melanie R Palomares, Tracy Graham, Lea Velsher, Janos Papp, Edith Oláh, Tsun L Chan, Suet Y Leung, Ad Geurts van Kessel, Lambertus A L M Kiemeney, Nicoline Hoogerbrugge, Marjolijn J L Ligtenberg Lancet Oncol. 2011 Jan;12(1):49-55.

2010

• The emerging mechanisms of isoform-specific PI3K signalling

  Bart Vanhaesebroeck, Julie Guillermet-Guibert, Mariona Graupera, Benoit Bilanges. Nat Rev Mol Cell Biol. 2010 May;11(5):329-41.

• Novel RUNX1 mutations in familial platelet disorder with enhanced risk for acute myeloid leukemia: clues for improved identification of the FPD/AML syndrome

  M C J Jongmans, R P Kuiper, C L Carmichael, E J Wilkins, N Dors, A Carmagnac, A Y N Schouten-van Meeteren, X Li, M Stankovic, E Kamping, H Bengtsson, E F P M Schoenmakers, A Geurts van Kessel, P M Hoogerbrugge, C N Hahn, P P Brons, H S Scott, N Hoogerbrugge Leukemia. 2010 Jan;24(1):242-6.

2009

• Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes

  Nejentsev S, Walker N, Riches D, Egholm M, Todd JA. Science. 2009 Apr 17;324(5925):387-9. 

• Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3′ exons of TACSTD1

  Marjolijn J L Ligtenberg, Roland P Kuiper, Tsun Leung Chan, Monique Goossens, Konnie M Hebeda, Marsha Voorendt, Tracy Y H Lee, Danielle Bodmer, Eveline Hoenselaar, Sandra J B Hendriks-Cornelissen, Wai Yin Tsui, Chi Kwan Kong, Han G Brunner, Ad Geurts van Kessel, Siu Tsan Yuen, J Han J M van Krieken, Suet Yi Leung, Nicoline Hoogerbrugge Nat Genet. 2009 Jan;41(1):112-7.

2008

• Bivalent domains enforce transcriptional memory of DNA methylated genes in colon cancer cells.

  Rodriguez J, Muñoz M, Vives L, Frangou C, Groudine M, Peinado M. Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19809-14. 

• The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma

  Guillermet-Guibert J, Bjorklof K, Salpekar A, Gonella C, Ramadani F, Bilancio A, Meek S, Smith AJ, Okkenhaug K, Vanhaesebroeck B. Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8292-7. 

• Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.

  Graupera M, Guillermet-Guibert J, Foukas LC, Phng LK, Cain RJ, Salpekar A, Pearce W, Meek S, Millan J, Cutillas PR, Smith AJ, Ridley AJ, Ruhrberg C, Gerhardt H, Vanhaesebroeck B. Nature. 2008 May 29;453(7195):662-6. 

2007

• Localisation of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

  Nejentsev S, Howson JM, Walker NM, Szeszko J, Field SF, Stevens HE, Reynolds P, Hardy M, King E, Masters J, Hulme J, Maier LM, Smyth D, Bailey R, Cooper JD, Ribas G, Campbell RD, Clayton DG, Todd JA; Wellcome Trust Case Control Consortium Nature. 2007 Dec 6;450(7171):887-92.

2005

• Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kgamma

  Vecchione C, Patrucco E, Marino G, Barberis L, Poulet R, Aretini A, Maffei A, Gentile MT, Storto M, Azzolino O, Brancaccio M, Colussi GL, Bettarini U, Altruda F, Silengo L, Tarone G, Wymann MP, Hirsch E, Lembo G. J Exp Med. 2005 Apr 18;201(8):1217-28.

• Cost effectiveness of a new strategy to identify HNPCC patients

  W Kievit, J H F M de Bruin, E M M Adang, J L Severens, J H Kleibeuker, R H Sijmons, T J Ruers, F M Nagengast, H F A Vasen, J H J M van Krieken, M J L Ligtenberg, N Hoogerbrugge Gut. 2005;54:97-102.

2004

• PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects

  Patrucco E, Notte A, Barberis L, Selvetella G, Maffei A, Brancaccio M, Marengo S, Russo G, Azzolino O, Rybalkin SD, Silengo L, Altruda F, Wetzker R, Wymann MP, Lembo G, Hirsch E. Cell. 2004 Aug 6;118(3):375-87.

2003

• High prevalence of premalignant lesions in prophylactically removed breasts from women at hereditary risk for breast cancer

  N Hoogerbrugge, P Bult, L M de Widt-Levert, L V Beex, L A Kiemeney, M J L Ligtenberg, L F Massuger, C Boetes, P Manders, H G Brunner J Clin Oncol. 2003 Jan 1;21(1):41-5.

2000

• Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation

  Hirsch E, Katanaev VL, Garlanda C, Azzolino O, Pirola L, Silengo L, Sozzani S, Mantovani A, Altruda F, Wymann MP. Science. 2000 Feb 11;287(5455):1049-53.