ABOUT PIPgen

The PIPgen network aims to train a unique cohort of creative and entrepreneurial ESRs in a wide range of scientific and complementary competences towards changing the European biomedical landscape in PI3K/PTEN-related diseases.

Through an international call and open recruitment procedure, we will recruit 15 PhD candidates to carry out specific projects under the supervision of a Principal Investigator within one of the 11 world-leading European host institutions from the network.

Our future fellows will be enrolled in a PhD programme and will receive an outstanding and tailored training designed specifically for them. In addition to the training offered by the university, supervisors, host institutions and mentors, the PhD candidates will also carry out secondments in other European institutions within the network to provide the needed interactions to achieve research and training excellence, and improve their future career perspectives. The embedding within the PIPgen network’s experts and experienced trainers from two sectors (academia and industry) and two research environments (clinical and basic) offers a unique multidisciplinary and multisectoral training opportunity in the field of PI3K/PTEN-related diseases.

Scientific project

PIPgen stems from the emerging links between monogenic rare diseases and cancer, and how these fields can cross-fertilise and inform an integrated approach to both their understanding and treatment. Monogenic diseases offer ‘clean’ molecular, cellular and organismal information about the affected genes, whereas cancer is a compendium of genetic and epigenetic perturbations illustrative of complex diseases. Genetic alterations in the phosphoinositide 3-kinase (PI3K)/PTEN pathway are a common event in both monogenic rare diseases and in cancer, presenting a truly unique paradigm of which PIPgen will take advantage. PIPgen aims to critically contribute by providing a dynamic learning strategy to enhance our understanding of the PI3K/PTEN pathway based on the molecular and biological integration of both pathological scenarios. PIPgen has been conceived with the view to make a real therapeutic impact without losing focus on the underpinning basic bioscience.

Host institutions

Josep Carreras Leukaemia Research Institute (IJC), Barcelona, Spain

Created in 2010, the IJC’s mission is to investigate the epidemiological, preventive, clinical, translation and basic aspects of leukaemia and other hematologic malignancies through innovation to cure them.

Projects 4, 13

IJC website

University College of London, London, UK

Founded in 1826 in the heart of London, UCL is London’s leading multidisciplinary university, with more than 13,000 staff and 42,000 students from 150 different countries.

Projects 1, 8

UCL website

Université de Paris, Paris, France

The University of Paris (French: Université de Paris) is a public university created by decree on 20 March 2019 and resulting from the merger of Paris Descartes (Paris V) and Paris Diderot (Paris VII) universities established following the division of the University of Paris (c. 1150–1793, 1896–1970), and the integration of Institut de physique du globe de Paris as a component institution. As of January 1, 2020, the universities of Paris Descartes and Paris Diderot have fully relinquished their rights and bonds at University of Paris.

Project 2

UP website

Erasmus MC, Rotterdam, Netherlands

Erasmus MC is one of the largest scientific University Medical Centres in Europe and is recognized as a world-class scientific research organization aiming to improve our understanding of diseases and disorders and helps to predict, treat and prevent them.

Project 7

ErasmusMC website

Institut national de la santé et de la recherche (Inserm) / Université de Toulouse III, Toulouse, France

Inserm is a public research organization entirely dedicated to human health. Its objective is to promote the health of all by advancing knowledge about life and disease, treatment innovation, and public health research.

Projects 9,12

Inserm website

Amsterdam University Medical Centres (UMC), Amsterdam, Netherlands

The Academic Medical Center, or AMC, is the university hospital affiliated with the University of Amsterdam. It is one of the largest and leading hospitals of the Netherlands, located in the Bijlmer neighborhood in the most south-eastern part of the city of Amsterdam.

Project 5

UMC website

Cambridge University (UCAM), Cambridge, UK

The University of Cambridge is a global institution. These pages provide an overview of Cambridge’s international activities in pursuit of its mission to contribute to society through excellence of education, learning and research.

Projects 6,11

UCAM website

Stichting Radboud universitair medisch centrum, Nijmegen, Netherlands

Researchers of the Radboud university medical center (Radboudumc, in short) focus on today’s scientific health challenges as well as keeping an eye on emerging diseases of the future.

Project 3

Radboud UMC website

CIC-biogune (cic-BIO), Bilbao, Spain

CIC bioGUNE, member of the Basque Research and Technology Alliance (BRTA), is a key research center within the national and international scientific landscape and has emerged as a knowledge source in the area of health science. The cutting-edge scientific activity of CIC bioGUNE researchers explores the interface between Chemistry, Structural, Molecular and Cell Biology, with the aim of developing a more Precise Medicine for the future.

Project 10

cic-BIO website

Kither Biotech (KITHER), Torino, Italy

Kither Biotech is a pharmaceutical product company that focuses its R&D activities on the development of new drugs. The R&D activities of the company mainly involve the development of new drugs to treat chronic inflammatory diseases.

Project 14

KITHER website

qGenomics (qG), Esplugues del Llobregat, Spain

qGenomics was founded on the principles of excellence in service and research that govern the institutions that watched us hatch (CRG y UPF). For this reason, we consider basic and applied research fundamental pieces of our daily work, and we are committed to continue being a leading provider of genomic tools for clinical use.

Project 15

qG website

Associated partners

iOnctura

Founded in June 2017 with molecules licensed from Merck KGaA and Cancer Research UK, iOnctura is a clinical stage biopharmaceutical company focused on delivering innovative cancer treatments to patients with unmet medical need.

iOnctura website

Sonja Noss

Specialised in international scientific high-performance environments, Sonja Noss offers Mindfulness-Based Systemic Coaching and Training solutions.

Sonja Noss website

KOM Agency

KOM Agency is a full services communication agency dedicated to Healthcare and Life Sciences pioneers.

KOM Agency website

Universitat de Barcelona (UB)

The University of Barcelona is synonymous with a vocation to serve citizens, making progress and innovation one of its highest goals.

UB website

Universidad del País Vasco (UPV)

The University of the Basque Country is a Spanish public university of the Basque Autonomous Community. Heir of the University of Bilbao, initially it was made up of the Faculty of Economic and Business Sciences of Sarriko, Medicine and Sciences.

UPV website

University of Turin (UNITO)

The University of Turin is a university in the city of Turin in the Piedmont region of north-western Italy. It is one of the oldest universities in Europe, and continues to play an important role in research and training.

UNITO website