The leading European network that tackles PI3K/PTEN-related monogenic disease to understand cancer.

PIPgen is an Innovative Training Network funded by the European Union’s Horizon 2020 research and innovation programme that envisions to empower PI3K/PTEN research in Europe to the next level of research and especially towards clinical translation.

The PIPgen network aims to train 15 ESRs in a wide range of scientific and complementary competences and prepare them for leading roles in the European industry and academia.
The PIPgen network aims to train a unique cohort of creative and entrepreneurial ESRs in a wide range of scientific and complementary competences towards changing the European biomedical landscape in PI3K/PTEN-related diseases.
PIPgen is a multidisciplinary and cross-sectorial consortium that brings together 11 leading European basic and clinical scientists and complementary industrial expertise in the PI3K/PTEN field.

Research focus

PIPgen stems from the emerging links between monogenic rare diseases and cancer, and how these fields can cross-fertilise into an integrated approach to both their understanding and treatment. Monogenic diseases offer ‘clean’ molecular, cellular and organismal information about the affected genes, whereas cancer is a compendium of genetic and epigenetic perturbations illustrative of complex diseases. Genetic alterations in the phosphoinositide 3-kinase (PI3K)/PTEN pathway are a common event in both monogenic rare diseases and in cancer. PIPgen aims to enhance our understanding of the PI3K/PTEN pathway based on the molecular and biological integration of both pathological scenarios.

Training programme

Through the participation of international leaders in the clinical, academic and industrial sectors, PIPgen aims to train the future European leaders experts on PI3K/PTEN and to bridge fundamental science to pre-clinical investigations and exploitation.
The 3-level training programme designed by PIPgen together with the networking opportunities that will be offered to the ESRs will nurture their professional career in different science-related sectors, ESRs will acquire excellent research skills in combination with team-leading abilities, project management and entrepreneurship.

Researchers will be enrolled in a PhD programme and will participate in soft skill courses, targeted workshops, conferences, retreats, social events and networking and they will carry out secondments in other European institutions within the network.